Scientists in the US successfully 3D-prints hair follicles within lab-grown human skin tissue

In a groundbreaking achievement, scientists at the Rensselaer Polytechnic Institute of New York have achieved the 3D printing of hair follicles within lab-grown human skin tissue, marking a historic milestone in biomedical engineering. Published in the journal Science Advances, this accomplishment is not only significant for its potential in treating baldness but also represents a major stride in regenerative medicine.

 

Hair follicles play a crucial role in regulating body temperature through sweat production and house stem cells vital for skin regeneration. The successful 3D printing of these structures within lab-grown skin not only holds promise for aesthetic applications but also opens new avenues in regenerative medicine.

 

This breakthrough has broader implications, particularly in the automation of processes related to biomanufacturing skin. The 3D cultivation of human-derived cells offers potential in generating new hair follicles and shafts, indicating progress in successful skin grafts. Traditionally, safety assessments relied on hairless engineered skin tissues, but incorporating hair follicles into skin models provides a more realistic platform for exploring skin interactions with various formulations. This, in turn, facilitates the testing of more effective treatments for a range of skin conditions.

 

The research team at Rensselaer Institute utilized 3D printing techniques tailored for cellular-level precision. The process involved cultivating skin and follicle cells until a sufficient quantity of printable cells was obtained. These cells were then combined with proteins and other materials to create a specialized “bio-ink” for the printer. Using an ultra-thin needle, the printer deposited the bio-ink layer by layer, creating channels for the placement of hair cells. Over time, skin cells migrated to these channels, replicating the natural follicle structures found in authentic skin.

 

In essence, this breakthrough represents a significant advancement in the realm of skin tissue engineering. The successful 3D printing of hair follicles, with the potential for 3D-printed skin grafts capable of growing hair, is poised to shape the future of medical procedures related to artificial hair transplants.