A global study has found that young breast cancer patients with high-risk BRCA mutations can significantly lower their chances of recurrence and improve survival rates by undergoing breast and/or ovary removal. Researchers analyzed data from 5,290 patients aged 40 or younger, treated at 109 hospitals across five continents, with a median follow-up of 8.2 years.
The study revealed that mastectomy reduced the risk of death by 35% and recurrence by 42%, while ovary removal lowered mortality risk by 42% and recurrence by 32%. Patients who underwent either or both surgeries showed comparable overall survival benefits.
Researchers hope the findings will enhance counseling on cancer-risk management for young BRCA carriers. The study was presented at the San Antonio Breast Cancer Symposium.
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